Search on: DNA TOPOISOMERASES 
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Descriptor English:   DNA Topoisomerases 
Descriptor Spanish:   Topoisomerasas de ADN 
Descriptor Portuguese:   DNA Topoisomerases 
Tree Number:   D08.811.399.403
Definition English:   Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are important components of the DNA replication system. They are classified by their substrate specificities. DNA TOPOISOMERASE I enzymes act on a single strand of DNA. DNA TOPOISOMERASE II enzymes act on double strands of DNA. 
History Note English:   2002 
Allowable Qualifiers English:  
administration & dosage adverse effects
antagonists & inhibitors analysis
biosynthesis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications drug effects
deficiency diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology physiology
pharmacokinetics poisoning
radiation effects supply & distribution
secretion standards
toxicity therapeutic use
ultrastructure urine
Record Number:   36083 
Unique Identifier:   D026942 

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